How the Microbiome Controls Testosterone Metabolism Via the Estrobolome
Most men optimizing hormones are focused on the HPG axis – LH, FSH, Leydig cell output, aromatase activity, SHBG. That's the right framework, but it's incomplete. There's a downstream regulatory layer that most practitioners and patients overlook entirely: the gut microbiome's direct influence on androgen and estrogen metabolism through a specialized subset of bacterial genes collectively called the estrobolome. If your free testosterone is suppressed, your estradiol is elevated, or your sex hormone profile doesn't respond as expected to protocol changes, the estrobolome is a legitimate and underexplored variable.
Updated: April 30, 2026 | Ryan Mitchell
Is Time-Restricted Eating Anabolic or Catabolic for Muscle?
Time-restricted eating (TRE) has moved well past the hype phase. The research base is solid enough to take seriously, and the practical appeal – a simple eating window as a lever for body composition, metabolic health, and longevity signaling – is real. But the question that serious lifters keep running into is the one that actually matters: what does compressing your eating window into 6–10 hours actually do to muscle protein synthesis, muscle retention, and anabolic hormone output?
Updated: April 30, 2026 | Ryan Mitchell
How the Microbiome Controls Testosterone Metabolism Via the Estrobolome
Updated: April 30, 2026 | Ryan Mitchell
Is Time-Restricted Eating Anabolic or Catabolic for Muscle?
